Vilanculos is situated on the Indian Ocean coast in Mozambique's Inhambane Province. This small coastal town is more than 700 km (435 miles) north of Maputo. Pelican Air flies from Johannesburg in South Africa to Vilanculos twice daily, direct and via South Africa's Kruger National Park. LAM offers flights from Maputo. The small Vilanculos airport is located just south of the town.

For families traveling to Vilanculos by air, taxis offer the best way to get around. While it may be possible to rent a car through your resort or lodge it is not advisable to travel by road at night. Day trips to the Bazaruto Archipelago can be arranged through most upscale lodges and resorts. Sail Away, located in Vilanculos, is one of the few independent operators offering transfers and excursions. Make the necessary enquires before hiring a dhow.

In Vilanculos, the weather is characterized by a wet and dry season. The best time to visit Vilanculos and the Bazaruto Archipelago is from June to September when the average daytime temperature is between 22-30° C (71-86° F) and the chance of rain is minimal. The weather is hot and humid throughout the rainy season (November - April); the heaviest rains are in January and February. In October and November the temperature begins to climb and so does the humidity. Cyclone Favio caused damage to the islands and many of the lodges are closed temporarily.

Traveler's diarrhea is the most common aliment afflicting tourists in Mozambique. Avoiding tap water is the cornerstones to prevention. Drink bottled water and eat cooked or peeled fruit and vegetables only. Malaria is prevalent throughout Mozambique and is a risk year-round.